rs4685022

This is a intergenic variant variant.

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GWAS Catalog Trait Associations (4)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

cerebral cortex area attribute

Shadrin AA et al. “Vertex-wise multivariate genome-wide association study identifies 780 unique genetic loci associated with cortical morphology.” Neuroimage 244:118603 (2021)

Allele A

OR —

p 2.0e-9

N 35,657

Large GWAS

European

perivascular space measurement

Duperron MG et al. “Genomics of perivascular space burden unravels early mechanisms of cerebral small vessel disease.” Nature Medicine 29(4):950-962 (2023)

Allele G

OR —

p 2.0e-9

N 38,598

Large GWAS

European

cortical thickness

Zhukovsky P et al. “Genetic influences on brain and cognitive health and their interactions with cardiovascular conditions and depression.” Nature Communications 15(1):5207 (2024)

Allele A

OR —

p 1.0e-9

N 34,532

Large GWAS

European

neuroimaging measurement

Smith SM et al. “An expanded set of genome-wide association studies of brain imaging phenotypes in UK Biobank.” Nature Neuroscience 24(5):737-745 (2021)

Allele G

OR 0.07

p 2.0e-12

N 21,282

Major Consortium StudyLarge GWAS

European

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

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