rs4693608

A case-control study investigating the association between heparanase gene (HPSE) polymorphisms and endometrial cancer susceptibility in 270 patients and 320 controls. The rs4693608 G/G genotype showed a protective effect against endometrial cancer (adjusted OR = 0.41, 95% CI = 0.21-0.81, p = 0.026 in codominant model; OR = 0.43, 95% CI = 0.22-0.82, p = 0.0076 in recessive model). rs4693608 was also associated with tumor grade and cervical invasion, while rs4364254 was associated with tumor grade only.

A case-control study of 155 gastric cancer patients and 204 healthy controls identified four SNPs in the HPSE-1 gene (heparanase). The AAG haplotype (intron3/exon8/exon13) was significantly associated with gastric cancer risk (OR=7.467, P<0.0001). SNP rs11099592 (Arg307Lys) variant genotypes were associated with Borrmann classification and tumor invasion depth (OR=0.182, P=0.015 and OR=0.341, P=0.020). SNP rs6856901 (exon13) GC/CC genotypes showed better tumor-related survival (OR=0.504, P=0.028).