rs4712653

This variant is located in the CASC15 gene.

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GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

neuroblastoma

Wang K et al. “Integrative genomics identifies LMO1 as a neuroblastoma oncogene.” Nature 469(7329):216-20 (2011)

Allele C

OR 1.40

p 8.0e-17

N 4,881

Large GWAS

European

Chang X et al. “Common variants in MMP20 at 11q22.2 predispose to 11q deletion and neuroblastoma risk.” Nature Communications 8(1):569 (2017)

Allele C

OR 1.86

p 1.0e-11

N 5,369

Large GWAS

European

About CASC15

This gene produces a long non-coding RNA that may regulate cell proliferation. This RNA is upregulated in hepatocellular carcinoma, where it is thought to function as an oncogene. However, some splice variants of this gene may function as a tumor suppressor in neuroblastoma and other tumor types. Circular RNA variants were observed at this gene. [provided by RefSeq, Dec 2017]

View all CASC15 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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