rs4713916

This study examined whether two FKBP5 polymorphisms (rs1360780 and rs3800373) predict antidepressant treatment response in 246 geriatric depression patients treated with paroxetine or mirtazapine in a double-blind randomized trial. Unlike previous reports, the authors found no significant associations between FKBP5 variants and treatment outcomes by HDRS-17 scores or time to remission, with only marginal non-significant findings on HDRS-21 measures that were opposite in direction to prior studies. The results suggest FKBP5 genetic variation may not play a major role in antidepressant response in elderly patients.

This cross-sectional study of 762 African American adults found that four FKBP5 SNPs (rs9296158, rs3800373, rs1360780, rs9470080; minimum P=0.0004) significantly interacted with severity of childhood abuse to predict adult PTSD symptoms, independent of non-child abuse trauma exposure, depression severity, age, sex, and genetic ancestry. The SNPs showed no main effects on PTSD or interactions with non-child abuse trauma, suggesting a specific gene-by-childhood-environment interaction mechanism.