rs4719433

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GWAS Catalog Trait Associations (3)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

type 2 diabetes mellitus

Suzuki K et al. “Genetic drivers of heterogeneity in type 2 diabetes pathophysiology.” Nature 627(8003):347-357 (2024)

Allele C

OR —

p 6.0e-102

N 2,535,601

Large GWAS

multi-ancestry

Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)

Allele C

OR 0.07

p 1.0e-15

N 116,014

Major Consortium StudyLarge GWAS

African American or Afro-Caribbean

Drugs used in diabetes use measurement

Sakaue S et al. “A cross-population atlas of genetic associations for 220 human phenotypes.” Nature Genetics 53(10):1415-1424 (2021)

Allele C

OR 0.06

p 3.0e-14

N 484,639

Large GWAS

multi-ancestry

BMI-adjusted fasting blood glucose measurement

Downie CG et al. “Multi-ethnic GWAS and fine-mapping of glycaemic traits identify novel loci in the PAGE Study.” Diabetologia 65(3):477-489 (2022)

Allele T

OR 0.04

p 2.0e-10

N 52,211

Large GWAS

multi-ancestry

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

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