rs472093

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GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

tumor necrosis factor receptor superfamily member 1B amount

Pietzner M et al. “Mapping the proteo-genomic convergence of human diseases.” Science (new York, N.y.) 374(6569):eabj1541 (2021)
Allele A
OR 0.17
p 2.0e-23
N 10,708
Large GWAS
European
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Research that mentions this SNP (1)

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SNP/haplotype associations in cytokine and cytokine receptor genes and immunity to rubella vaccine
AssociationN=738Neelam Dhiman et al.(2010)· Immunogenetics

A candidate gene study of 738 healthy children examined associations between SNPs/haplotypes in cytokine and cytokine receptor genes and immune response to rubella vaccination. SNPs rs2844482 and rs2857708 in the TNFA promoter were associated with increased rubella-specific IgG antibodies (p=0.0002 and p=0.001, respectively). Multiple SNPs in TNFRSF1B and IL12B genes were associated with IL-6 secretion levels, and the TNFA haplotype AAACGGGGC was associated with higher rubella antibody response (t-statistic=3.32, p<0.001).

Traits studied:GM-CSF secretionIFN-gamma secretionIL-2 secretionIL-6 secretionRubella vaccination immune responseRubella-specific IgG antibody responseTNF-alpha secretion
PubMedDOIMetascience Observatory

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

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