rs4734879

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GWAS Catalog Trait Associations (14)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

vascular endothelial growth factor A level

Sun BB et al. “Genomic atlas of the human plasma proteome.” Nature 558(7708):73-79 (2018)

Allele G

OR —

β 0.310

p 7.0e-30

N 3,301

Large GWAS

European

Gudjonsson A et al. “A genome-wide association study of serum proteins reveals shared loci with common diseases.” Nature Communications 13(1):480 (2022)

Allele G

OR 0.23

p 2.0e-22

N 5,364

Large GWAS

European

platelet count

Yang Z et al. “Genetic basis of pregnancy-associated decreased platelet counts and gestational thrombocytopenia.” Blood 143(15):1528-1538 (2024)

Allele G

OR 0.08

p 2.0e-28

N 72,816

Large GWAS

East Asian

Burley K et al. “PIK3R3 is a candidate regulator of platelet count in people of Bangladeshi ancestry.” Research and Practice in Thrombosis and Haemostasis 7(4):100175 (2023)

Allele G

OR 0.10

p 6.0e-18

N 20,218

Large GWAS

South Asian

platelet-to-lymphocyte ratio

Kachuri L et al. “Genetic determinants of blood-cell traits influence susceptibility to childhood acute lymphoblastic leukemia.” American Journal of Human Genetics 108(10):1823-1835 (2021)

Allele A

OR —

p 1.0e-24

N 234,552

Large GWAS

European

platelet quantity

Akbari P et al. “A genome-wide association study of blood cell morphology identifies cellular proteins implicated in disease aetiology.” Nature Communications 14(1):5023 (2023)

Allele G

OR 0.07

p 3.0e-20

N 37,935

Large GWAS

European

leukocyte quantity

Sakaue S et al. “A cross-population atlas of genetic associations for 220 human phenotypes.” Nature Genetics 53(10):1415-1424 (2021)

Allele G

OR 0.02

p 6.0e-20

N 504,825

Large GWAS

multi-ancestry

venous thromboembolism

Klarin D et al. “Genome-wide association analysis of venous thromboembolism identifies new risk loci and genetic overlap with arterial vascular disease.” Nature Genetics 51(11):1574-1579 (2019)

Allele A

OR 1.09

p 4.0e-19

N 650,119

Large GWAS

multi-ancestry

platelet glycoprotein 4 level

Pietzner M et al. “Mapping the proteo-genomic convergence of human diseases.” Science (new York, N.y.) 374(6569):eabj1541 (2021)

Allele A

OR 0.13

p 1.0e-18

N 10,708

Large GWAS

European

level of collagen alpha-1(V) chain in blood

Loya H et al. “A scalable variational inference approach for increased mixed-model association power.” Nature Genetics 57(2):461-468 (2025)

Allele G

OR 0.05

p 1.0e-17

N 47,745

Large GWAS

European

matrix metalloproteinase 1 measurement

Zhao JH et al. “Genetics of circulating inflammatory proteins identifies drivers of immune-mediated disease risk and therapeutic targets.” Nature Immunology 24(9):1540-1551 (2023)

Allele A

OR 0.11

p 1.0e-16

N 14,744

Large GWAS

multi-ancestry

level of sialomucin core protein 24 in blood

Loya H et al. “A scalable variational inference approach for increased mixed-model association power.” Nature Genetics 57(2):461-468 (2025)

Allele G

OR 0.05

p 9.0e-14

N 47,745

Large GWAS

European

This variant is in our database but has no known associations or PRS memberships yet.

rs4734879

GWAS Catalog Trait Associations (14)

vascular endothelial growth factor A level

platelet count

platelet-to-lymphocyte ratio

platelet quantity

leukocyte quantity

venous thromboembolism

platelet glycoprotein 4 level

level of collagen alpha-1(V) chain in blood

matrix metalloproteinase 1 measurement

level of sialomucin core protein 24 in blood

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