rs4740273

This variant is located in the PRRT1B gene.

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GWAS Catalog Trait Associations (2)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

level of carcinoembryonic antigen-related cell adhesion molecule 5 in blood

Loya H et al. “A scalable variational inference approach for increased mixed-model association power.” Nature Genetics 57(2):461-468 (2025)

Allele G

OR 0.06

p 1.0e-35

N 47,745

Large GWAS

European

advanced glycosylation end product-specific receptor amount

Pietzner M et al. “Mapping the proteo-genomic convergence of human diseases.” Science (new York, N.y.) 374(6569):eabj1541 (2021)

Allele A

OR 0.16

p 1.0e-32

N 10,708

Large GWAS

European

Folkersen L et al. “Genomic and drug target evaluation of 90 cardiovascular proteins in 30,931 individuals.” Nature Metabolism 2(10):1135-1148 (2020)

Allele A

OR 0.12

p 2.0e-32

N 21,758

Large GWAS

European

Thareja G et al. “Differences and commonalities in the genetic architecture of protein quantitative trait loci in European and Arab populations.” Human Molecular Genetics 32(6):907-916 (2023)

Allele A

OR 0.24

p 2.0e-18

N 2,935

Large GWAS

Greater Middle Eastern (Middle Eastern, North African or Persian)

About PRRT1B

Predicted to be active in membrane. [provided by Alliance of Genome Resources, Jul 2025]

View all PRRT1B variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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