rs4740619

This variant is located in the CCDC171 gene.

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GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

body mass index

Huang J et al. “Genomics and phenomics of body mass index reveals a complex disease network.” Nature Communications 13(1):7973 (2022)

Allele C

OR 0.02

p 2.0e-33

N 1,122,049

Large GWAS

European

Pulit SL et al. “Meta-analysis of genome-wide association studies for body fat distribution in 694 649 individuals of European ancestry.” Human Molecular Genetics 28(1):166-174 (2019)

Allele C

OR 0.02

p 3.0e-31

N 806,834

Meta-analysisLarge GWAS

European

Koskeridis F et al. “Pleiotropic genetic architecture and novel loci for C-reactive protein levels.” Nature Communications 13(1):6939 (2022)

Allele C

OR 0.02

p 1.0e-31

N 694,649

Large GWAS

European

Sidorenko J et al. “Genetic architecture reconciles linkage and association studies of complex traits.” Nature Genetics 56(11):2352-2360 (2024)

Allele C

OR 0.02

p 3.0e-27

N 650,000

Large GWAS

European

Hoffmann TJ et al. “A Large Multiethnic Genome-Wide Association Study of Adult Body Mass Index Identifies Novel Loci.” Genetics 210(2):499-515 (2018)

Allele C

OR —

β 0.016

p 4.0e-10

N 334,487

Large GWAS

multi-ancestry

Winkler TW et al. “The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study.” Plos Genetics 11(10):e1005378 (2015)

Allele C

OR —

β 0.017

p 2.0e-10

N 309,889

Large GWAS

European

Locke AE et al. “Genetic studies of body mass index yield new insights for obesity biology.” Nature 518(7538):197-206 (2015)

Allele C

OR 0.02

p 6.0e-9

N 238,944

Large GWAS

multi-ancestry

Akiyama M et al. “Genome-wide association study identifies 112 new loci for body mass index in the Japanese population.” Nature Genetics 49(10):1458-1467 (2017)

Allele C

OR 0.02

p 3.0e-10

N 158,284

Large GWAS

multi-ancestry

This variant is in our database but has no known associations or PRS memberships yet.

rs4740619

GWAS Catalog Trait Associations (1)

body mass index

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