rs4742903
This variant is located in the SMC2 gene.
▶GWAS Catalog Trait Associations (1)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (1)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
breast carcinoma
Zhang H et al. “Genome-wide association study identifies 32 novel breast cancer susceptibility loci from overall and subtype-specific analyses.” Nature Genetics 52(6):572-581 (2020)
Allele C
OR 1.03
p 3.0e-8
N 247,173
Large GWAS
European
About SMC2
Predicted to enable chromatin binding activity. Involved in mitotic chromosome condensation and positive regulation of chromosome condensation. Located in condensed chromosome; cytoplasm; and nuclear lumen. Part of condensin complex. Implicated in colon adenocarcinoma. Biomarker of colorectal cancer. [provided by Alliance of Genome Resources, Jul 2025]
View all SMC2 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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