rs4745021
This is a intron variant variant in the TRPM3 gene.
▶GWAS Catalog Trait Associations (1)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (1)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
thyroid nodule
Hwangbo Y et al. “Genome-Wide Association Study Reveals Distinct Genetic Susceptibility of Thyroid Nodules From Thyroid Cancer.” The Journal of Clinical Endocrinology and Metabolism 103(12):4384-4394 (2018)
Allele T
OR 1.28
p 2.0e-8
N 1,502
Large GWAS
East Asian
About TRPM3
The product of this gene belongs to the family of transient receptor potential (TRP) channels. TRP channels are cation-selective channels important for cellular calcium signaling and homeostasis. The protein encoded by this gene mediates calcium entry, and this entry is potentiated by calcium store depletion. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
View all TRPM3 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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