rs4764695

A genome-wide association study (GWAS) of 506-937 bipolar affective disorder cases and 510-990 controls identified multiple SNPs in the IGF1 gene associated with bipolar disorder, with four SNPs showing p-values of 3.7×10⁻⁵, 8.4×10⁻⁴, 2.6×10⁻⁴, and 2.5×10⁻⁴. Resequencing identified novel variants in IGF1, including rs5742620 (p=0.0454) and rs78352613 (p=0.006) in the promoter region. Gene-wide analysis and haplotypic association confirmed IGF1 as a candidate susceptibility gene for bipolar disorder with dominant inheritance pattern.

This case-control study examined genetic variants in IGF-I, IGFBP-1, and IGFBP-3 genes in relation to proliferative benign breast disease (BBD) in 359 cases and 359 controls from the Nurses' Health Study II. Higher circulating IGFBP-3 levels were significantly associated with increased BBD risk (OR 1.70, p-trend = 0.03), while minor alleles of IGFBP-3 SNPs rs3110697 and rs2132570 were associated with significantly lower BBD risk (OR 0.6 and 0.2, p-trend = 0.02). Three other IGFBP-3 SNPs (rs2854744, rs2960436, rs2854746) were strongly associated with circulating IGFBP-3 levels.

This study investigated the association between common genetic variation in IGF1, IGFBP1, and IGFBP3 genes and mammographic density in 819 women from the Multiethnic Cohort. Only weak evidence was found for associations: rs35767 (IGF1, p=0.03) was associated with 3.2% lower mammographic density, rs35539615 (IGFBP1, p=0.05) with higher density, and rs2453839 (IGFBP3, p=0.01) with lower density. Ethnicity significantly modified the associations for IGFBP3 variants.