rs4765353

This variant is located in the ZNF664-RFLNA gene.

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GWAS Catalog Trait Associations (2)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

glaucoma

Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)

Allele G

OR 0.05

p 6.0e-18

N 609,053

Major Consortium StudyLarge GWAS

multi-ancestry

cup-to-disc ratio measurement

Craig JE et al. “Multitrait analysis of glaucoma identifies new risk loci and enables polygenic prediction of disease susceptibility and progression.” Nature Genetics 52(2):160-166 (2020)

Allele G

OR 0.01

p 2.0e-9

N 67,040

Large GWAS

European

About ZNF664-RFLNA

This locus represents naturally occurring read-through transcription between the neighboring zinc finger protein 664 (Gene ID: 144348) and refilin A (Gene ID: 144347) genes on chromosome 12. The read-through transcript produces a protein that shares sequence identity with the downstream refilin A gene product. [provided by RefSeq, Dec 2016]

View all ZNF664-RFLNA variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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