rs4765623

This is a intron variant variant in the SCARB1 gene.

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GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

clear cell renal carcinoma

Purdue MP et al. “Multi-ancestry genome-wide association study of kidney cancer identifies 63 susceptibility regions.” Nature Genetics 56(5):809-818 (2024)
Allele T
OR 1.15
p 3.0e-23
N 759,800
Large GWAS
multi-ancestry
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Research that mentions this SNP (1)

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Combining fMRI and SNP data to investigate connections between brain function and genetics using parallel ICA
MethodsN=63Jingyu Liu et al.(2009)· Human Brain Mapping

This paper presents parallel Independent Component Analysis (ICA), a novel multivariate method for jointly analyzing functional MRI and SNP data to identify connections between brain function and genetic variation. Applied to 63 participants (20 schizophrenia patients, 43 controls), the method extracted linked components from 367 SNPs and fMRI data, identifying a genetic component containing SNPs in genes such as DISC1 (rs821616), ADRA2A (rs2429511), and CHRNA7 (rs3087454) that correlated with fMRI-derived brain networks involved in the auditory oddball task.

Traits studied:Auditory oddball taskBrain activation patternsSchizophrenia
PubMedDOIMetascience Observatory

About SCARB1

The protein encoded by this gene is a plasma membrane receptor for high density lipoprotein cholesterol (HDL). The encoded protein mediates cholesterol transfer to and from HDL. In addition, this protein is a receptor for hepatitis C virus glycoprotein E2 and facilitates cell entry by the virus, SARS-CoV2. [provided by RefSeq, Oct 2021]

View all SCARB1 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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