rs4766598

This variant is located in the MYO1H gene.

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GWAS Catalog Trait Associations (2)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

protein measurement

He B et al. “Genome-wide pQTL analysis of protein expression regulatory networks in the human liver.” Bmc Biology 18(1):97 (2020)

Allele G

OR —

β 0.023

p 4.0e-17

N 287

Small GWAS

multi-ancestry

depressive symptom measurement

Li ZY et al. “Whole exome sequencing identified six novel genes for depressive symptoms.” Molecular Psychiatry 30(5):1925-1936 (2025)

Allele G

OR 0.01

p 1.0e-8

N 296,199

Large GWAS

European

About MYO1H

Predicted to enable actin filament binding activity and microfilament motor activity. Predicted to be involved in actin filament organization; actin filament-based movement; and endocytosis. Predicted to be part of myosin complex. Predicted to be active in several cellular components, including actin cytoskeleton; microvillus; and plasma membrane. Implicated in congenital central hypoventilation syndrome. [provided by Alliance of Genome Resources, Jul 2025]

View all MYO1H variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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