rs4790522
This is a 3 prime utr variant variant in the TRPV1 gene.
▶Research that mentions this SNP (1)
▶SNP variants within the vanilloidTRPV1andTRPV3receptor genes are associated with migraine in the Spanish populationAssociationN=2,077Oriel Carreño et al.(2012)· American Journal of Medical Genetics Part B: Neuropsychiatric Genetics
Case-control genetic association study with replication examining 149 SNPs in 14 TRP channel genes across 1,040 migraine cases and 1,037 controls in a Spanish population. TRPV3 rs7217270 was associated with migraine with aura (MA) and TRPV1 rs222741 with overall migraine in replication. Risk haplotypes in TRPC1, TRPC4, TRPV1, TRPV3, TRPV4, TRPM6, and TRPM8 were identified in the discovery phase (ORs 1.37-2.42) but not replicated.
About TRPV1
Capsaicin, the main pungent ingredient in hot chili peppers, elicits a sensation of burning pain by selectively activating sensory neurons that convey information about noxious stimuli to the central nervous system. The protein encoded by this gene is a receptor for capsaicin and is a non-selective cation channel that is structurally related to members of the TRP family of ion channels. This receptor is also activated by increases in temperature in the noxious range, suggesting that it functions as a transducer of painful thermal stimuli in vivo. Four transcript variants encoding the same protein, but with different 5' UTR sequence, have been described for this gene. [provided by RefSeq, Jul 2008]
View all TRPV1 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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