rs4811602

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GWAS Catalog Trait Associations (4)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

heart rate response to exercise

Cai L et al. “Causal associations between cardiorespiratory fitness and type 2 diabetes.” Nature Communications 14(1):3904 (2023)

Allele G

OR 0.34

p 2.0e-22

N 69,416

Large GWAS

European

diastolic blood pressure

Jee YH et al. “Genome-wide association studies in a large Korean cohort identify quantitative trait loci for 36 traits and illuminate their genetic architectures.” Nature Communications 16(1):4935 (2025)

Allele A

OR 0.01

p 1.0e-10

N 928,679

Large GWAS

multi-ancestry

maximal oxygen uptake measurement

Hanscombe KB et al. “The genetic case for cardiorespiratory fitness as a clinical vital sign and the routine prescription of physical activity in healthcare.” Genome Medicine 13(1):180 (2021)

Allele G

OR 0.03

p 4.0e-9

N 70,783

Large GWAS

European

right ventricular stroke volume measurement

Schmidt AF et al. “Druggable proteins influencing cardiac structure and function: Implications for heart failure therapies and cancer cardiotoxicity.” Science Advances 9(17):eadd4984 (2023)

Allele G

OR —

p 3.0e-8

N 35,932

Large GWAS

European

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

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