rs4820294
This variant is located in the LGALS1 gene.
▶Research that mentions this SNP (1)
▶Genetic variants in apoptosis‐related genes associated with colorectal hyperplasiaAssociationN=860Stefano Gerola et al.(2014)· Genes, Chromosomes and Cancer
A two-stage candidate gene association study identified genetic variants in apoptosis-related genes associated with colorectal hyperplastic polyps (HP). Stage I genotyped 1,536 SNPs in 826 apoptosis-related genes in 784 samples (272 cases, 512 controls), identifying 14 candidate SNPs with P < 0.01. Stage II validated these in 76 samples (38 cases, 38 controls). Meta-analysis with FDR correction identified 9 SNPs with combined P < 0.01 associated with HP, including rs4709583 (PARK2, q=0.003), rs10476829 (HDAC3), rs7083622 and rs11016073 (MKI67). Functional studies showed rs10476829 altered HDAC3 mRNA half-life through cryptic polyadenylation.
About LGALS1
The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell-cell and cell-matrix interactions. This gene product may act as an autocrine negative growth factor that regulates cell proliferation. [provided by RefSeq, Jul 2008]
View all LGALS1 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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