rs4854344
▶GWAS Catalog Trait Associations (2)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (2)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
physical activity measurement, body mass index
Graff M et al. “Genome-wide physical activity interactions in adiposity - A meta-analysis of 200,452 adults.” Plos Genetics 13(4):e1006528 (2017)
Allele T
OR 0.07
p 2.0e-22
N 161,368
Meta-analysisLarge GWAS
multi-ancestry
body mass index
Graff M et al. “Genome-wide physical activity interactions in adiposity - A meta-analysis of 200,452 adults.” Plos Genetics 13(4):e1006528 (2017)
Allele T
OR 0.09
p 2.0e-11
N 38,595
Meta-analysisLarge GWAS
multi-ancestry
▶Research that mentions this SNP (1)
▶Association of genetic variants for susceptibility to obesity with type 2 diabetes in Japanese individualsAssociationN=18,264Takeuchi F. et al.(2011)· Diabetologia
Association of genetic variants for susceptibility to obesity with type 2 diabetes in Japanese individuals
AssociationN=18,264Takeuchi F. et al.(2011)· Diabetologia
Replication study of 14 obesity-associated SNPs from 13 loci in 18,264 Japanese participants, confirming associations at 11 loci including TMEM18 (rs4854344, p=7.1×10⁻⁷ for BMI), FTO, MC4R, BDNF, and others. Six obesity variants also associated with type 2 diabetes after BMI adjustment (OR 1.05-1.17), with FTO showing strong meta-analyzed association in East Asians (OR 1.13, p=7.8×10⁻¹⁰).
Traits studied:Body Mass Index (BMI)ObesityType 2 DiabetesWaist-to-Hip RatioWeight
This variant is in our database but has no known associations or PRS memberships yet.
Gene information from NCBI Gene. Variant classifications from ClinVar.
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