rs485660

This is a upstream gene variant variant in the SYPL2 gene.

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Research that mentions this SNP (1)

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A GWAS follow‐up of obesity‐related SNPs in SYPL2 reveals sex‐specific association with hip circumference
AssociationN=3,693de Toro-Martín J. et al.(2016)· Obesity Science & Practice

This two-stage association study followed up an obesity-related SNP in SYPL2 to reveal novel associations with hip circumference (HC). In a combined cohort of 3,693 individuals, rs9661614 (T>C) was significantly associated with HC in women (FDR-corrected p=1.7×10⁻²), with heterozygotes showing ~1.3-1.4 cm narrower hips compared to homozygotes. A second SNP, rs485660 (G>A), showed weaker evidence (FDR p=0.2 in women). The associations were sex-specific, present in women but absent in men, suggesting SYPL2 preferentially affects gynoid fat distribution.

Traits studied:Blood pressureBody mass indexFasting glucoseHDL cholesterolHip circumferenceLDL cholesterolObesityTotal cholesterolTriglyceridesWaist circumferenceWaist-to-hip ratio
PubMedDOIMetascience Observatory

About SYPL2

Involved in substantia nigra development. Predicted to be located in membrane and synaptic vesicle. Predicted to be active in synaptic vesicle membrane. [provided by Alliance of Genome Resources, Jul 2025]

View all SYPL2 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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