rs4863692

This variant is located in the MAML3 gene.

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GWAS Catalog Trait Associations (3)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

self reported educational attainment

Okbay A et al. “Genome-wide association study identifies 74 loci associated with educational attainment.” Nature 533(7604):539-42 (2016)

Allele T

OR —

β 0.017

p 5.0e-12

N 405,072

Large GWAS

European

Alzheimer disease, educational attainment

Kulminski AM et al. “Pleiotropic predisposition to Alzheimer's disease and educational attainment: insights from the summary statistics analysis.” Geroscience 44(1):265-280 (2022)

Allele T

OR 53.57

p 6.0e-11

N 4,029

Large GWAS

body mass index

Huang J et al. “Genomics and phenomics of body mass index reveals a complex disease network.” Nature Communications 13(1):7973 (2022)

Allele G

OR 0.01

p 8.0e-10

N 1,122,049

Large GWAS

European

About MAML3

Enables transcription coactivator activity. Involved in Notch signaling pathway and positive regulation of transcription by RNA polymerase II. Located in nuclear speck. [provided by Alliance of Genome Resources, Jul 2025]

View all MAML3 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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