rs4869742
This is a intron variant variant in the CCDC170 gene.
▶GWAS Catalog Trait Associations (3)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (3)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
bone tissue density
Estrada K et al. “Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture.” Nature Genetics 44(5):491-501 (2012)
Allele T
OR —
β 0.080
p 4.0e-35
N 32,961
Meta-analysisLarge GWAS
multi-ancestry
Surakka I et al. “MEPE loss-of-function variant associates with decreased bone mineral density and increased fracture risk.” Nature Communications 11(1):4093 (2020)
Allele T
OR 0.11
p 2.0e-19
N 21,907
Large GWAS
European
body composition measurement
Wu Z et al. “Genetic architecture of bone marrow fat fraction implies its involvement in osteoporosis risk.” Nature Communications 16(1):7490 (2025)
Allele T
OR 0.08
p 2.0e-24
N 38,560
Large GWAS
European
bone fracture
Morris JA et al. “An atlas of genetic influences on osteoporosis in humans and mice.” Nature Genetics 51(2):258-266 (2019)
Allele C
OR 0.03
p 2.0e-23
N 426,795
Large GWAS
European
About CCDC170
The function of this gene and its encoded protein is not known. Several genome-wide association studies have implicated the region around this gene to be involved in breast cancer and bone mineral density, but no link to this specific gene has been found. [provided by RefSeq, May 2010]
View all CCDC170 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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