rs4878690

This variant is located in the GRHPR gene.

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GWAS Catalog Trait Associations (2)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

level of glyoxylate reductase/hydroxypyruvate reductase in blood

Loya H et al. “A scalable variational inference approach for increased mixed-model association power.” Nature Genetics 57(2):461-468 (2025)

Allele T

OR 0.23

p 2.0e-297

N 47,745

Large GWAS

European

protein measurement

Pietzner M et al. “Mapping the proteo-genomic convergence of human diseases.” Science (new York, N.y.) 374(6569):eabj1541 (2021)

Allele T

OR 0.43

p 1.0e-214

N 10,708

Large GWAS

European

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ClinVar annotation

Benign★★★☆

3 submitters1 publication

Primary hyperoxaluria, type II; not provided

View on ClinVar →

About GRHPR

This gene encodes an enzyme with hydroxypyruvate reductase, glyoxylate reductase, and D-glycerate dehydrogenase enzymatic activities. The enzyme has widespread tissue expression and has a role in metabolism. Type II hyperoxaluria is caused by mutations in this gene. [provided by RefSeq, Jul 2008]

View all GRHPR variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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