rs4921492

This is a intergenic variant variant.

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GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

sarcoidosis

Fischer A et al. “Identification of Immune-Relevant Factors Conferring Sarcoidosis Genetic Risk.” American Journal of Respiratory and Critical Care Medicine 192(6):727-36 (2015)
Allele A
OR 1.20
p 2.0e-9
N 7,208
Large GWAS
multi-ancestry
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Research that mentions this SNP (1)

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Single nucleotide polymorphisms of IL12B are associated with Takayasu arteritis in Chinese Han population
AssociationN=1,009Xiaoting Wen et al.(2017)· Rheumatology International

Case-control study of 412 Chinese Han Takayasu arteritis patients and 597 controls identified four IL12B SNPs significantly associated with disease susceptibility: rs6871626 (OR=1.52, 95% CI 1.26-1.83), rs4921492 (OR=1.46), rs60689680 (OR=1.41), and rs4921493 (OR=1.45). Meta-analysis across four populations confirmed rs6871626 as a susceptible locus (pooled OR=1.51). IL6 rs2069837 showed no association.

Traits studied:Takayasu arteritis
PubMedDOIMetascience Observatory

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

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