rs4921790
This variant is located in the PDGFRL gene.
▶GWAS Catalog Trait Associations (1)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (1)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
hippocampal volume
Chung J et al. “Genome-wide association study of Alzheimer's disease endophenotypes at prediagnosis stages.” Alzheimer's & Dementia : the Journal of the Alzheimer's Association 14(5):623-633 (2018)
Allele C
OR 0.61
p 5.0e-9
N 305
Small GWAS
European
About PDGFRL
This gene encodes a protein with significant sequence similarity to the ligand binding domain of platelet-derived growth factor receptor beta. Mutations in this gene, or deletion of a chromosomal segment containing this gene, are associated with sporadic hepatocellular carcinomas, colorectal cancers, and non-small cell lung cancers. This suggests this gene product may function as a tumor suppressor. [provided by RefSeq, Jul 2008]
View all PDGFRL variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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