rs4923463

This is a downstream gene variant variant in the BDNF-AS gene.

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GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

body weight

Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)
Allele A
OR 0.05
p 8.0e-31
N 609,196
Major Consortium StudyLarge GWAS
multi-ancestry
Sakaue S et al. “A cross-population atlas of genetic associations for 220 human phenotypes.” Nature Genetics 53(10):1415-1424 (2021)
Allele A
OR 0.03
p 3.0e-26
N 165,419
Large GWAS
East Asian
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Research that mentions this SNP (2)

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Association study of brain‐derived neurotrophic factor (BDNF) and LIN‐7 homolog (LIN‐7) genes with adult attention‐deficit/hyperactivity disorder
AssociationN=201Matthew Lanktree et al.(2008)· American Journal of Medical Genetics Part B: Neuropsychiatric Genetics

Association study of BDNF and LIN-7 genes with adult ADHD using 80 family trios and 121 case-control pairs (201 total probands). Five BDNF SNPs and two LIN-7 SNPs were tested; the functional Val66Met polymorphism (rs6265) and BDNF_2 (rs11030104) showed significant associations after multiple testing correction with odds ratios of 1.65 (p=0.0096) and 1.66 (p=0.0085) respectively. LIN-7_1 (rs10835188) was also significantly associated with adult ADHD.

Traits studied:Adult ADHDAttention-deficit/hyperactivity disorder (ADHD)
PubMedDOIMetascience Observatory
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Significant association of BDNF haplotypes in European‐American male smokers but not in European‐American female or African‐American smokers
FunctionalN=300Joke Beuten et al.(2005)· American Journal of Medical Genetics Part B: Neuropsychiatric Genetics

This study analyzed genotype-expression interactions for BDNF across five human brain regions using GTEx data from 300 subjects (985 tissue samples). At FDR < 0.1, 61 SNPs in cerebellum, 55 in cortex, 48 in nucleus accumbens, 47 in caudate, and 58 in cerebellar hemisphere were associated with BDNF expression. Thirty SNPs in two haplotype blocks were shared across all five regions, including rs6265 (Val66Met), rs16917204, rs11030104, and rs6484320, which have been previously associated with psychiatric disorders including depression, bipolar disorder, schizophrenia, OCD, epilepsy, and addiction.

Traits studied:Alzheimer's diseaseBDNF expressionBipolar disorderDepressionEating disordersEpilepsyMethamphetamine abuseNicotine addictionObsessive-compulsive disorderPanic disorderPost-traumatic stress disorderSchizophreniaSubstance use disorders
PubMedDOIMetascience Observatory

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

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