rs4934436

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GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

tumor necrosis factor receptor superfamily member 6 measurement

Folkersen L et al. “Genomic and drug target evaluation of 90 cardiovascular proteins in 30,931 individuals.” Nature Metabolism 2(10):1135-1148 (2020)
Allele T
OR 0.12
p 4.0e-47
N 21,758
Large GWAS
European
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Research that mentions this SNP (1)

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Identification of modifier genes for cutaneous malignant melanoma in melanoma‐prone families with and without CDKN2A mutations
AssociationN=537Xiaohong Rose Yang et al.(2009)· International Journal of Cancer

This study identified modifier genes for cutaneous malignant melanoma (CMM) in 537 individuals from 28 melanoma-prone families (107 CMM cases), with and without CDKN2A mutations. Using conditional logistic regression and pathway-based analysis of 1,536 SNPs in 152 genes involved in DNA repair, apoptosis, and immune response pathways, the study found that IL9 remained significant after Bonferroni correction (P<0.05), with other candidate genes including FAS, BCL7A, CASP14, TRAF6, WRN, IL10RB, TNFSF8, TNFRSF9, and JAK3 showing associations with CMM risk (P<0.01, gene-based test). SNPs rs12827036 (BCL7A), rs7270207 (BCL2L1), and rs2069882 (IL9) showed significant interactions with CDKN2A status.

Traits studied:Cutaneous malignant melanoma (CMM)Dysplastic nevi (DN)
PubMedDOIMetascience Observatory

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

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