rs4951018
This variant is located in the SLC45A3 gene.
▶GWAS Catalog Trait Associations (4)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (4)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
prostate specific antigen amount
Hoffmann TJ et al. “Genome-wide association study of prostate-specific antigen levels in 392,522 men identifies new loci and improves prediction across ancestry groups.” Nature Genetics 57(2):334-344 (2025)
Allele A
OR 0.03
p 3.0e-55
N 392,522
Large GWAS
multi-ancestry
Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)
Allele A
OR 0.04
p 2.0e-21
N 254,502
Major Consortium StudyLarge GWAS
European
Kachuri L et al. “Genetically adjusted PSA levels for prostate cancer screening.” Nature Medicine 29(6):1412-1423 (2023)
Allele A
OR 0.03
p 3.0e-13
N 95,768
Large GWAS
multi-ancestry
Hoffmann TJ et al. “Genome-wide association study of prostate-specific antigen levels identifies novel loci independent of prostate cancer.” Nature Communications 8:14248 (2017)
Allele A
OR 0.04
p 1.0e-8
N 28,503
Large GWAS
multi-ancestry
sialic acid-binding Ig-like lectin 6 amount
Loya H et al. “A scalable variational inference approach for increased mixed-model association power.” Nature Genetics 57(2):461-468 (2025)
Allele C
OR 0.05
p 5.0e-19
N 47,745
Large GWAS
European
cholesteryl esters to total lipids in IDL percentage
Zoodsma M et al. “A genetic map of human metabolism across the allele frequency spectrum.” Nature Genetics 57(10):2445-2455 (2025)
Allele C
OR 0.02
p 5.0e-12
N 450,015
Large GWAS
multi-ancestry
total lipids in large VLDL
Zoodsma M et al. “A genetic map of human metabolism across the allele frequency spectrum.” Nature Genetics 57(10):2445-2455 (2025)
Allele C
OR 0.02
p 1.0e-11
N 450,015
Large GWAS
multi-ancestry
About SLC45A3
Predicted to enable sucrose:proton symporter activity. Predicted to be involved in positive regulation of small molecule metabolic process; regulation of oligodendrocyte differentiation; and sucrose transport. Predicted to be located in plasma membrane. Predicted to be active in membrane. [provided by Alliance of Genome Resources, Jul 2025]
View all SLC45A3 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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