rs4962691
This is a intron variant variant in the FAM53B gene.
▶GWAS Catalog Trait Associations (3)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (3)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
hippocampal volume
Liu N et al. “Cross-ancestry genome-wide association meta-analyses of hippocampal and subfield volumes.” Nature Genetics 55(7):1126-1137 (2023)
Allele T
OR 0.06
p 4.0e-31
N 65,791
Large GWAS
European, East Asian
smoking initiation
Saunders GRB et al. “Genetic diversity fuels gene discovery for tobacco and alcohol use.” Nature 612(7941):720-724 (2022)
Allele T
OR 0.01
p 7.0e-16
N 3,382,012
Large GWAS
European, East Asian, Hispanic or Latin American, African unspecified
glomerular filtration rate
Morris AP et al. “Trans-ethnic kidney function association study reveals putative causal genes and effects on kidney-specific disease aetiologies.” Nature Communications 10(1):29 (2019)
Allele T
OR 0.29
p 5.0e-10
N 312,296
Large GWAS
multi-ancestry
About FAM53B
Involved in positive regulation of canonical Wnt signaling pathway. Located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]
View all FAM53B variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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