rs4963772

This is a intergenic variant variant.

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GWAS Catalog Trait Associations (4)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

heart rate

Loya H et al. “A scalable variational inference approach for increased mixed-model association power.” Nature Genetics 57(2):461-468 (2025)
Allele A
OR 0.06
p 1.0e-100
N 394,642
Large GWAS
European
Eppinga RN et al. “Identification of genomic loci associated with resting heart rate and shared genetic predictors with all-cause mortality.” Nature Genetics 48(12):1557-1563 (2016)
Allele A
OR 0.71
p 3.0e-53
N 134,251
Large GWAS
multi-ancestry
Ramírez J et al. “Thirty loci identified for heart rate response to exercise and recovery implicate autonomic nervous system.” Nature Communications 9(1):1947 (2018)
Allele A
OR 0.77
p 7.0e-18
N 67,062
Large GWAS
European

heart rate variability measurement

Tegegne BS et al. “Phenotypic but not genetically predicted heart rate variability associated with all-cause mortality.” Communications Biology 6(1):1013 (2023)
Allele G
OR 0.85
p 3.0e-35
N 46,075
Large GWAS
European
Kerr KF et al. “Genome-wide association study of heart rate and its variability in Hispanic/Latino cohorts.” Heart Rhythm 14(11):1675-1684 (2017)
Allele G
OR 0.07
p 2.0e-9
N 13,767
Large GWAS
multi-ancestry

heart rate response to exercise

Verweij N et al. “Genetic study links components of the autonomous nervous system to heart-rate profile during exercise.” Nature Communications 9(1):898 (2018)
Allele G
OR 0.09
p 6.0e-28
N 58,818
Large GWAS
multi-ancestry
Hanscombe KB et al. “The genetic case for cardiorespiratory fitness as a clinical vital sign and the routine prescription of physical activity in healthcare.” Genome Medicine 13(1):180 (2021)
Allele G
OR 0.01
p 6.0e-11
N 70,783
Large GWAS
European

heart rate response to recovery post exercise

Ramírez J et al. “Thirty loci identified for heart rate response to exercise and recovery implicate autonomic nervous system.” Nature Communications 9(1):1947 (2018)
Allele G
OR 0.50
p 2.0e-11
N 67,257
Large GWAS
European
Verweij N et al. “Genetic study links components of the autonomous nervous system to heart-rate profile during exercise.” Nature Communications 9(1):898 (2018)
Allele G
OR 0.09
p 1.0e-26
N 58,818
Large GWAS
multi-ancestry
Diamant N et al. “Deep learning on resting electrocardiogram to identify impaired heart rate recovery.” Cardiovascular Digital Health Journal 3(4):161-170 (2022)
Allele G
OR 0.24
p 2.0e-8
N 43,722
Major Consortium StudyLarge GWAS
European

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

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