rs4974081

This variant is located in the QRICH1 gene.

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Research that mentions this SNP (1)

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Consortium analysis of gene and gene–folate interactions in purine and pyrimidine metabolism pathways with ovarian carcinoma risk
AssociationN=36,045Linda E. Kelemen et al.(2014)· Molecular Nutrition & Food Research

Consortium analysis of 13,410 ovarian cancer cases and 22,635 controls examining 446 genetic variants in folate metabolism and purine/pyrimidine pathways. The strongest associations were DPYD rs11587873 (OR=0.92, p=6×10⁻⁵) and rs828054 (OR=1.06, p=1×10⁻⁴). While 13 pyrimidine metabolism variants showed significant folate intake interactions, they explained only 0.2% of ovarian carcinoma risk, suggesting limited clinical utility for folate-stratified risk modification.

Traits studied:Clear cell ovarian cancerEndometrioid ovarian cancerHigh-grade serous ovarian cancerLow-grade serous ovarian cancerMucinous ovarian cancerOvarian carcinoma
PubMedDOIMetascience Observatory

About QRICH1

Enables DNA binding activity. Involved in intracellular signal transduction; positive regulation of DNA-templated transcription; and positive regulation of apoptotic process. Located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

View all QRICH1 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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