rs4985155
This is a downstream gene variant variant in the PDXDC1 gene.
▶GWAS Catalog Trait Associations (12)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (12)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
fatty acid amount
Sun Y et al. “GWAS and multi-omics integrative analysis reveal novel loci and their molecular mechanisms for circulating fatty acids.” Hgg Advances 6(4):100470 (2025)
Allele G
OR —
p 2.0e-22
N 110,346
Large GWAS
European
cholesterol to total lipids in medium LDL percentage
Zoodsma M et al. “A genetic map of human metabolism across the allele frequency spectrum.” Nature Genetics 57(10):2445-2455 (2025)
Allele G
OR 0.02
p 6.0e-18
N 450,015
Large GWAS
multi-ancestry
dihomo-gamma-linolenic acid measurement
Yang C et al. “Genome-wide association studies and fine-mapping identify genomic loci for n-3 and n-6 polyunsaturated fatty acids in Hispanic American and African American cohorts.” Communications Biology 6(1):852 (2023)
Allele G
OR 7.72
p 1.0e-14
N 1,454
Large GWAS
Hispanic or Latin American
1-dihomo-linoleoyl-GPC (20:2) measurement
Surendran P et al. “Rare and common genetic determinants of metabolic individuality and their effects on human health.” Nature Medicine 28(11):2321-2332 (2022)
Allele A
OR 0.08
p 2.0e-13
N 14,296
Large GWAS
European
body mass index
Sidorenko J et al. “Genetic architecture reconciles linkage and association studies of complex traits.” Nature Genetics 56(11):2352-2360 (2024)
Allele A
OR 0.01
p 6.0e-13
N 650,000
Large GWAS
European
Pulit SL et al. “Meta-analysis of genome-wide association studies for body fat distribution in 694 649 individuals of European ancestry.” Human Molecular Genetics 28(1):166-174 (2019)
Allele A
OR 0.01
p 3.0e-9
N 806,834
Meta-analysisLarge GWAS
European
Koskeridis F et al. “Pleiotropic genetic architecture and novel loci for C-reactive protein levels.” Nature Communications 13(1):6939 (2022)
Allele A
OR 0.01
p 3.0e-10
N 694,649
Large GWAS
European
triglyceride measurement, body mass index
Huang LO et al. “Genome-wide discovery of genetic loci that uncouple excess adiposity from its comorbidities.” Nature Metabolism 3(2):228-243 (2021)
Allele A
OR —
p 1.0e-12
N 517,085
Large GWAS
multi-ancestry
1-linoleoyl-GPC (18:2) measurement
Surendran P et al. “Rare and common genetic determinants of metabolic individuality and their effects on human health.” Nature Medicine 28(11):2321-2332 (2022)
Allele A
OR 0.07
p 2.0e-10
N 14,296
Large GWAS
European
femoral neck bone mineral density
Estrada K et al. “Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture.” Nature Genetics 44(5):491-501 (2012)
Allele A
OR —
β 0.030
p 2.0e-10
N 32,961
Meta-analysisLarge GWAS
multi-ancestry
level of phosphatidylethanolamine
Cadby G et al. “Comprehensive genetic analysis of the human lipidome identifies loci associated with lipid homeostasis with links to coronary artery disease.” Nature Communications 13(1):3124 (2022)
Allele G
OR 0.14
p 4.0e-9
N 4,492
Large GWAS
European
left ventricular mass
Khurshid S et al. “Clinical and genetic associations of deep learning-derived cardiac magnetic resonance-based left ventricular mass.” Nature Communications 14(1):1558 (2023)
Allele A
OR 1.00
p 6.0e-9
N 43,230
Large GWAS
multi-ancestry
About PDXDC1
Enables cadherin binding activity. Predicted to be involved in carboxylic acid metabolic process. Located in Golgi apparatus. [provided by Alliance of Genome Resources, Jul 2025]
View all PDXDC1 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
Community Wiki
No community notes yet for this variant. Sign in to start one.
Comments
Sign in to join the discussion.
Loading comments…