rs528557

This is a synonymous variant in the ADAM33 gene — it does not change the protein's amino acid sequence.

▶

Research that mentions this SNP (1)

▶
Genetic determinants in the development of sensitization to environmental allergens in early childhood
ReviewPriya Tripathi et al.(2014)· Immunity, Inflammation and Disease

This is Part 2 of a review on house dust mite (HDM) allergen sensitization in children, discussing genetic factors that influence IgE responses and clinical manifestations of HDM allergy. The review summarizes recent advances in understanding the role of gene polymorphisms (including HLA-DRB1, IL-4, IL-10, VDR, TNF-α, IL-18) in HDM sensitization development, and covers diagnostic approaches and allergen-specific immunotherapy (ASIT) effectiveness for HDM-induced allergic diseases.

Traits studied:Allergic diseasesAllergic rhinitisAsthmaAtopic dermatitisHouse dust mite sensitization
PubMedDOIMetascience Observatory

About ADAM33

This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. This protein is a type I transmembrane protein implicated in asthma and bronchial hyperresponsiveness. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2013]

View all ADAM33 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

Community Wiki

No community notes yet for this variant. Sign in to start one.

Comments

Sign in to join the discussion.

Loading comments…