rs533030436

This variant is located in the LRRC37A2 gene.

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GWAS Catalog Trait Associations (2)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

heart shape trait

Burns R et al. “Genetic basis of right and left ventricular heart shape.” Nature Communications 15(1):9437 (2024)

Allele A

OR 0.04

p 1.0e-9

N 35,055

Large GWAS

European

diastolic blood pressure

Giri A et al. “Trans-ethnic association study of blood pressure determinants in over 750,000 individuals.” Nature Genetics 51(1):51-62 (2019)

Allele G

OR 0.23

p 3.0e-8

N 459,777

Large GWAS

multi-ancestry

About LRRC37A2

Predicted to enable ATP binding activity; ATP hydrolysis activity; and metal ion binding activity. Predicted to be involved in SNARE complex disassembly and protein transport. Predicted to be located in cytoplasm and membrane. [provided by Alliance of Genome Resources, Jul 2025]

View all LRRC37A2 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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