rs542831

This is a upstream gene variant variant in the SIK2 gene.

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GWAS Catalog Trait Associations (2)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

level of serine protease inhibitor Kazal-type 4 in blood

Loya H et al. “A scalable variational inference approach for increased mixed-model association power.” Nature Genetics 57(2):461-468 (2025)

Allele A

OR 0.06

p 2.0e-26

N 47,745

Large GWAS

European

asthma

Johansson Å et al. “Genome-wide association analysis of 350 000 Caucasians from the UK Biobank identifies novel loci for asthma, hay fever and eczema.” Human Molecular Genetics 28(23):4022-4041 (2019)

Allele T

OR —

p 5.0e-13

N 281,699

Major Consortium StudyLarge GWAS

European

About SIK2

Enables ATP binding activity; magnesium ion binding activity; and protein kinase activity. Involved in intracellular signal transduction and protein autophosphorylation. Is active in endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Jul 2025]

View all SIK2 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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