rs545608

This variant is located in the SEC16B gene.

▶

GWAS Catalog Trait Associations (4)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

type 2 diabetes mellitus

Vujkovic M et al. “Discovery of 318 new risk loci for type 2 diabetes and related vascular outcomes among 1.4 million participants in a multi-ancestry meta-analysis.” Nature Genetics 52(7):680-691 (2020)
Allele G
OR 0.04
p 7.0e-10
N 1,114,458
Meta-analysisLarge GWAS
European

body mass index

Tachmazidou I et al. “Whole-Genome Sequencing Coupled to Imputation Discovers Genetic Signals for Anthropometric Traits.” American Journal of Human Genetics 100(6):865-884 (2017)
Allele C
OR 0.05
p 4.0e-9
N 56,793
Large GWAS
European
Helgeland Ø et al. “Characterization of the genetic architecture of infant and early childhood body mass index.” Nature Metabolism 4(3):344-358 (2022)
Allele C
OR 0.09
p 3.0e-8
N 14,280
Large GWAS
European

body fat distribution

Rask-Andersen M et al. “Genome-wide association study of body fat distribution identifies adiposity loci and sex-specific genetic effects.” Nature Communications 10(1):339 (2019)
Allele C
OR —
β 0.027
p 6.0e-12
N 116,138
Large GWAS
European

About SEC16B

SEC16B is a mammalian homolog of S. cerevisiae Sec16 that is required for organization of transitional endoplasmic reticulum (ER) sites and protein export (Bhattacharyya and Glick, 2007 [PubMed 17192411]).[supplied by OMIM, Jun 2009]

View all SEC16B variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

Community Wiki

No community notes yet for this variant. Sign in to start one.

Comments

Sign in to join the discussion.

Loading comments…