rs549326362

This variant is located in the FBXL17 gene.

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GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

post-traumatic stress disorder symptom measurement

Stein MB et al. “Genome-wide association analyses of post-traumatic stress disorder and its symptom subdomains in the Million Veteran Program.” Nature Genetics 53(2):174-184 (2021)

Allele T

OR —

β 0.088

p 4.0e-8

N 186,689

Major Consortium StudyLarge GWAS

European

About FBXL17

Members of the F-box protein family, such as FBXL17, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]

View all FBXL17 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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