rs552995590

This variant is located in the S100Z gene.

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GWAS Catalog Trait Associations (2)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

corticotropin-releasing factor-binding protein measurement

Loya H et al. “A scalable variational inference approach for increased mixed-model association power.” Nature Genetics 57(2):461-468 (2025)

Allele A

OR 0.48

p 2.0e-22

N 47,745

Large GWAS

European

drug use measurement, celiac disease

Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)

Allele G

OR 2.08

p 3.0e-11

N 371,173

Major Consortium StudyLarge GWAS

multi-ancestry

About S100Z

Members of the S100 protein family contain 2 calcium-binding EF-hands and exhibit cell-type specific expression patterns. For additional background information on S100 proteins, see MIM 114085.[supplied by OMIM, Mar 2008]

View all S100Z variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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