rs557051451

This variant is located in the MPHOSPH9 gene.

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GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

Alzheimer disease, family history of Alzheimer’s disease

Willett JDS et al. “Identification of 16 novel Alzheimer's disease loci using multi-ancestry meta-analyses.” Alzheimer's & Dementia : the Journal of the Alzheimer's Association 21(2):e14592 (2025)

Allele G

OR —

p 7.0e-11

N 404,467

Large GWAS

multi-ancestry

About MPHOSPH9

Involved in negative regulation of cilium assembly. Located in Golgi apparatus; centriole; and centrosome. Implicated in multiple sclerosis. [provided by Alliance of Genome Resources, Jul 2025]

View all MPHOSPH9 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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