rs55768116

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GWAS Catalog Trait Associations (3)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

lung adenocarcinoma

Qin N et al. “Comprehensive functional annotation of susceptibility variants identifies genetic heterogeneity between lung adenocarcinoma and squamous cell carcinoma.” Frontiers of Medicine 15(2):275-291 (2021)

Allele C

OR 0.89

p 4.0e-15

N 42,936

Large GWAS

East Asian, European

Dai J et al. “Identification of risk loci and a polygenic risk score for lung cancer: a large-scale prospective cohort study in Chinese populations.” The Lancet. Respiratory Medicine 7(10):881-891 (2019)

Allele C

OR 1.15

p 3.0e-10

N 42,936

Large GWAS

multi-ancestry

non-small cell lung carcinoma

Qin N et al. “Comprehensive functional annotation of susceptibility variants identifies genetic heterogeneity between lung adenocarcinoma and squamous cell carcinoma.” Frontiers of Medicine 15(2):275-291 (2021)

Allele C

OR 0.91

p 2.0e-13

N 54,475

Large GWAS

multi-ancestry

Dai J et al. “Identification of risk loci and a polygenic risk score for lung cancer: a large-scale prospective cohort study in Chinese populations.” The Lancet. Respiratory Medicine 7(10):881-891 (2019)

Allele C

OR 1.13

p 2.0e-9

N 54,475

Large GWAS

multi-ancestry

lung carcinoma

Wei X et al. “Development and evaluation of a polygenic risk score for lung cancer in never-smoking women: A large-scale prospective Chinese cohort study.” International Journal of Cancer 154(5):807-815 (2024)

Allele C

OR 1.15

p 4.0e-9

N 16,870

Large GWAS

East Asian

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

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