rs56077333

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GWAS Catalog Trait Associations (3)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

FEV/FVC ratio, response to bronchodilator

Lutz SM et al. “A genome-wide association study identifies risk loci for spirometric measures among smokers of European and African ancestry.” Bmc Genetics 16:138 (2015)

Allele A

OR —

β 0.018

p 1.0e-19

N 13,532

Large GWAS

multi-ancestry

forced expiratory volume, response to bronchodilator

Lutz SM et al. “A genome-wide association study identifies risk loci for spirometric measures among smokers of European and African ancestry.” Bmc Genetics 16:138 (2015)

Allele A

OR —

β 0.084

p 5.0e-18

N 13,532

Large GWAS

multi-ancestry

lung carcinoma

Betti MJ et al. “Genetic analysis in African ancestry populations reveals genetic contributors to lung cancer susceptibility.” American Journal of Human Genetics 112(9):2102-2114 (2025)

Allele A

OR 1.35

p 3.0e-8

N 4,877

Large GWAS

African American or Afro-Caribbean

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

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