rs56166763

This is a intron variant variant in the MAML3 gene.

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GWAS Catalog Trait Associations (2)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

smoking initiation

Saunders GRB et al. “Genetic diversity fuels gene discovery for tobacco and alcohol use.” Nature 612(7941):720-724 (2022)

Allele C

OR 0.01

p 4.0e-49

N 3,382,012

Large GWAS

European, East Asian, Hispanic or Latin American, African unspecified

Non-steroidal anti-inflammatory and antirheumatic product use measurement

Wu Y et al. “Genome-wide association study of medication-use and associated disease in the UK Biobank.” Nature Communications 10(1):1891 (2019)

Allele C

OR 0.04

p 1.0e-8

N 164,520

Major Consortium StudyLarge GWAS

European

About MAML3

Enables transcription coactivator activity. Involved in Notch signaling pathway and positive regulation of transcription by RNA polymerase II. Located in nuclear speck. [provided by Alliance of Genome Resources, Jul 2025]

View all MAML3 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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