rs562331457
This is a coding sequence variant variant in the GLG1 gene.
▶GWAS Catalog Trait Associations (2)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (2)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
drug use measurement, amyotrophic lateral sclerosis
Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)
Allele G
OR 3.01
p 1.0e-11
N 371,173
Major Consortium StudyLarge GWAS
multi-ancestry
drug use measurement, celiac disease
Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)
Allele G
OR 2.91
p 4.0e-11
N 371,173
Major Consortium StudyLarge GWAS
multi-ancestry
About GLG1
Predicted to enable fibroblast growth factor binding activity. Predicted to act upstream of or within several processes, including negative regulation of protein processing; negative regulation of transforming growth factor beta receptor signaling pathway; and regulation of chondrocyte differentiation. Located in Golgi apparatus. [provided by Alliance of Genome Resources, Jul 2025]
View all GLG1 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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