rs572200533

This variant is located in the ZNF420 gene.

ClinVar annotation

Uncertain Significance☆☆☆
1 submitter

not specified

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About ZNF420

The protein encoded by this gene is a KRAB-type zinc finger protein that negatively-regulates p53-mediated apoptosis. Under stress conditions, the encoded protein is phosphorylated by ATM and dissociates from p53, which activates p53 and initiates apoptosis. [provided by RefSeq, Jul 2016]

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Gene information from NCBI Gene. Variant classifications from ClinVar.

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