rs572537530

This variant is located in the MYRF gene.

▶

GWAS Catalog Trait Associations (12)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

omega-3 polyunsaturated fatty acid measurement

Sun Y et al. “GWAS and multi-omics integrative analysis reveal novel loci and their molecular mechanisms for circulating fatty acids.” Hgg Advances 6(4):100470 (2025)

Allele C

OR —

p 9.0e-45

N 239,268

Large GWAS

European

linoleic acid measurement

Sun Y et al. “GWAS and multi-omics integrative analysis reveal novel loci and their molecular mechanisms for circulating fatty acids.” Hgg Advances 6(4):100470 (2025)

Allele C

OR —

p 7.0e-14

N 239,268

Large GWAS

European

polyunsaturated fatty acids to monounsaturated fatty acids ratio

Sun Y et al. “GWAS and multi-omics integrative analysis reveal novel loci and their molecular mechanisms for circulating fatty acids.” Hgg Advances 6(4):100470 (2025)

Allele C

OR —

p 4.0e-12

N 239,268

Large GWAS

European

cholesteryl ester 20:4 measurement

Cadby G et al. “Comprehensive genetic analysis of the human lipidome identifies loci associated with lipid homeostasis with links to coronary artery disease.” Nature Communications 13(1):3124 (2022)

Allele C

OR 0.98

p 2.0e-9

N 4,492

Large GWAS

European

lysophosphatidylcholine 20:4 measurement

Allele C

OR 0.97

p 3.0e-9

N 4,492

Large GWAS

European

polyunsaturated fatty acid measurement

Sun Y et al. “GWAS and multi-omics integrative analysis reveal novel loci and their molecular mechanisms for circulating fatty acids.” Hgg Advances 6(4):100470 (2025)

Allele C

OR —

p 3.0e-9

N 239,268

Large GWAS

European

level of diglyceride

Allele C

OR 0.91

p 3.0e-8

N 4,492

Large GWAS

European

degree of unsaturation measurement

Sun Y et al. “GWAS and multi-omics integrative analysis reveal novel loci and their molecular mechanisms for circulating fatty acids.” Hgg Advances 6(4):100470 (2025)

Allele C

OR —

p 7.0e-16

N 110,346

Large GWAS

European

docosahexaenoic acid measurement

Sun Y et al. “GWAS and multi-omics integrative analysis reveal novel loci and their molecular mechanisms for circulating fatty acids.” Hgg Advances 6(4):100470 (2025)

Allele C

OR —

p 1.0e-22

N 239,268

Large GWAS

European

docosahexaenoic acid to total fatty acids percentage

Sun Y et al. “GWAS and multi-omics integrative analysis reveal novel loci and their molecular mechanisms for circulating fatty acids.” Hgg Advances 6(4):100470 (2025)

Allele C

OR —

p 7.0e-22

N 239,268

Large GWAS

European

About MYRF

This gene encodes a transcription factor that is required for central nervous system myelination and may regulate oligodendrocyte differentiation. It is thought to act by increasing the expression of genes that effect myelin production but may also directly promote myelin gene expression. Loss of a similar gene in mouse models results in severe demyelination. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014]

rs572537530

GWAS Catalog Trait Associations (12)

omega-3 polyunsaturated fatty acid measurement

linoleic acid measurement

polyunsaturated fatty acids to monounsaturated fatty acids ratio

cholesteryl ester 20:4 measurement

lysophosphatidylcholine 20:4 measurement

polyunsaturated fatty acid measurement

level of diglyceride

degree of unsaturation measurement

docosahexaenoic acid measurement

docosahexaenoic acid to total fatty acids percentage

About MYRF

Community Wiki

Comments