rs57382045

This is a intron variant variant in the TNFRSF13B gene.

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GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

IGA glomerulonephritis

Kiryluk K et al. “Genome-wide association analyses define pathogenic signaling pathways and prioritize drug targets for IgA nephropathy.” Nature Genetics 55(7):1091-1105 (2023)

Allele A

OR 1.16

p 3.0e-9

N 25,852

Large GWAS

multi-ancestry

About TNFRSF13B

The protein encoded by this gene is a lymphocyte-specific member of the tumor necrosis factor (TNF) receptor superfamily. It interacts with calcium-modulator and cyclophilin ligand (CAML). The protein induces activation of the transcription factors NFAT, AP1, and NF-kappa-B and plays a crucial role in humoral immunity by interacting with a TNF ligand. This gene is located within the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, Jul 2008]

View all TNFRSF13B variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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