rs574087

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GWAS Catalog Trait Associations (3)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

smoking initiation

Saunders GRB et al. “Genetic diversity fuels gene discovery for tobacco and alcohol use.” Nature 612(7941):720-724 (2022)

Allele G

OR 0.01

p 2.0e-30

N 3,382,012

Large GWAS

European, East Asian, Hispanic or Latin American, African unspecified

alopecia areata

Betz RC et al. “Genome-wide meta-analysis in alopecia areata resolves HLA associations and reveals two new susceptibility loci.” Nature Communications 6:5966 (2015)

Allele A

OR 1.32

p 9.0e-14

N 7,565

Meta-analysis

European

social inhibition quality, attention deficit hyperactivity disorder, substance abuse

Karlsson Linnér R et al. “Multivariate analysis of 1.5 million people identifies genetic associations with traits related to self-regulation and addiction.” Nature Neuroscience 24(10):1367-1376 (2021)

Allele A

OR 0.01

p 9.0e-11

N 2,776,348

Large GWAS

European

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

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