rs5743810
This is a variant in the TLR6 gene that changes a serine to an alanine.
▶ClinVar annotation
▶Research that mentions this SNP (1)
▶Polymorphism of the rs1800896 IL10
promoter gene protects children from post-bronchiolitis asthmaAssociationN=166Petri Koponen et al.(2014)· Pediatric Pulmonology
A prospective cohort study of 166 children hospitalized for bronchiolitis at <6 months of age, followed to mean age 6.5 years. Non-RSV bronchiolitis (OR 3.74) and genetic variants in IL10 rs1800896, MBL2 (non-A/A genotype, OR 3.15), and TLR1 rs5743618 were associated with increased preschool asthma risk (12.7% prevalence). IL10 A/A genotype was protective (3.1% asthma).
About TLR6
The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor functionally interacts with toll-like receptor 2 to mediate cellular response to bacterial lipoproteins. A Ser249Pro polymorphism in the extracellular domain of the encoded protein may be associated with an increased of asthma is some populations.[provided by RefSeq, Jan 2011]
View all TLR6 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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