rs5757678

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GWAS Catalog Trait Associations (2)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

N-glycan measurement

Sharapov S et al. “A genome-wide association study in 10,000 individuals links plasma N-glycome to liver disease and anti-inflammatory proteins.” Nature Communications 16(1):5525 (2025)

Allele C

OR 0.07

p 4.0e-73

N 7,540

Large GWAS

multi-ancestry

Rudman N et al. “Integrated glycomics and genetics analyses reveal a potential role for N-glycosylation of plasma proteins and IgGs, as well as the complement system, in the development of type 1 diabetes.” Diabetologia 66(6):1071-1083 (2023)

Allele C

OR 0.08

p 1.0e-11

N 1,074

Large GWAS

serum IgG glycosylation measurement

Rudman N et al. “Integrated glycomics and genetics analyses reveal a potential role for N-glycosylation of plasma proteins and IgGs, as well as the complement system, in the development of type 1 diabetes.” Diabetologia 66(6):1071-1083 (2023)

Allele G

OR 0.39

p 2.0e-13

N 1,086

Large GWAS

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

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