rs5758268

This is a downstream gene variant variant in the L3MBTL2 gene.

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GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

mood instability measurement

Nagel M et al. “Item-level analyses reveal genetic heterogeneity in neuroticism.” Nature Communications 9(1):905 (2018)

Allele A

OR 6.32

p 3.0e-10

N 373,733

Large GWAS

European

About L3MBTL2

Enables methylated histone binding activity. Predicted to be involved in negative regulation of DNA-templated transcription. Predicted to act upstream of or within several processes, including ectoderm development; stem cell differentiation; and stem cell proliferation. Located in nucleus. [provided by Alliance of Genome Resources, Apr 2025]

View all L3MBTL2 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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